Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

@article{Stocker2002LivingWL,
  title={Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.},
  author={Hugo Stocker and Mirjana Andjelkovic and Sean Oldham and Muriel Laffargue and Matthias P Wymann and Brian A. Hemmings and Ernst Hafen},
  journal={Science},
  year={2002},
  volume={295 5562},
  pages={2088-91}
}
The phosphoinositide phosphatase PTEN is mutated in many human cancers. Although the role of PTEN has been studied extensively, the relative contributions of its numerous potential downstream effectors to deregulated growth and tumorigenesis remain uncertain. We provide genetic evidence in Drosophila melanogaster for the paramount importance of the protein kinase Akt [also called protein kinase B (PKB)] in mediating the effects of increased phosphatidylinositol 3,4,5-trisphosphate (PIP3… CONTINUE READING

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