Living systems are tonically inhibited, autonomous optimizers, and disinhibition coupled to variability generation is their major organizing principle: Inhibitory command-control at levels of membrane, genome, metabolism, brain, and society

@article{Roberts1991LivingSA,
  title={Living systems are tonically inhibited, autonomous optimizers, and disinhibition coupled to variability generation is their major organizing principle: Inhibitory command-control at levels of membrane, genome, metabolism, brain, and society},
  author={Eugene Roberts},
  journal={Neurochemical Research},
  year={1991},
  volume={16},
  pages={409-421}
}
It is proposed that the major organizing principle in living systems is disinhibition coupled to variability generation. Facile traverse of adaptive functional ranges is made possible by activities of inhibitory (attenuating and/or time-delaying) influences. These maintain barriers to physicochemical perturbations, so that interactions between the external environment and living systems produce transient local changes (signals) that are transduced by a variety of devices at hand to release… CONTINUE READING

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GABA: The road to neurotransmitter status

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Highly Influential
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