Living and Dying for Sex

@article{Bowen2004LivingAD,
  title={Living and Dying for Sex},
  author={Richard L. Bowen and Craig S Atwood},
  journal={Gerontology},
  year={2004},
  volume={50},
  pages={265 - 290}
}
A mechanistic understanding of aging has yet to be described; this paper puts forth a new theory that has the potential to explain aging in all sexually reproductive life forms. The theory also puts forth a new definition of aging – any change in an organism over time. This definition includes not only the changes associated with the loss of function (i.e. senescence, the commonly accepted definition of aging), but also the changes associated with the gain of function (growth and development… 

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References

SHOWING 1-10 OF 316 REFERENCES

Kleemeier award lecture: are there genes for aging?

  • R. Miller
  • Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 1999
It is shown that aging can be affected by genetic variations within a species, but identification of genetic differences that discriminate long-lived from short-lived species will require a combination of genetic and physiological analyses.

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.

Endocrinology and Aging

The inevitability of hormone-mediated senescence in the female reproductive system well in advance of death of the organism has long focused attention on the possibility that hormones mediate the

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

It is shown that mice homozygous for loss-of-function mutations at the Pit1 (Snell dwarf) locus show a >40% increase in mean and maximal longevity on the relatively long-lived (C3H/HeJ × DW/J)F1 background, demonstrating that a single gene can control maximum lifespan and the timing of both cellular and extracellular senescence in a mammal.

Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials.

Bats have maximum life spans a minimum of 3 times those of nonflying eutherians--a trend resulting from neither low basal metabolic rate, the ability to enter torpor, nor large relative brain size, consistent with an evolutionary theory that posits exceptionally long life spans among mammals with reduced environmental vulnerability.

Mitotic misregulation and human aging.

Measurements ofenger RNA levels in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life.

DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease

It is concluded that the AD neurons complete a nearly full S phase, but because mitosis is not initiated, the cells remain tetraploid, and it is proposed that this imbalance is the direct cause of the neuronal loss in Alzheimer's disease.

Endocrine Alterations in the Aging Male

The study demonstrates that determining complete profiles of the androgenic, gonadotropic, adrenocortical, thyroid, pituitary and growth hormone/IGF endocrine axes in middle-aged and elderly men may be helpful in obtaining a correct clinical diagnosis for various hormonal disorders.

Caloric restriction and aging in primates: Relevance to humans and possible CR mimetics

Even if CR can be shown to impact upon human aging, it is unlikely that most people will be able to maintain the strict dietary control required for this regimen, so elucidation of the biological mechanisms of CR and development of alternative strategies to yield similar benefits is of primary importance.
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