Living Autologous Heart Valves Engineered From Human Prenatally Harvested Progenitors

@article{Schmidt2006LivingAH,
  title={Living Autologous Heart Valves Engineered From Human Prenatally Harvested Progenitors},
  author={D{\"o}rthe Schmidt and A. Driessen Mol and Christian Breymann and Josef Achermann and Bernhard Odermatt and Matthias G{\"o}ssi and S Stefan Neuenschwander and Ren{\'e} Pr{\^e}tre and Michele Genoni and Gregor Zund and Simon P. Hoerstrup},
  journal={Circulation},
  year={2006},
  volume={114},
  pages={I-125-I-131}
}
Background— Heart valve tissue engineering is a promising strategy to overcome the lack of autologous growing replacements, particularly for the repair of congenital malformations. Here, we present a novel concept using human prenatal progenitor cells as new and exclusive cell source to generate autologous implants ready for use at birth. Methods and Results— Human fetal mesenchymal progenitors were isolated from routinely sampled prenatal chorionic villus specimens and expanded in vitro. A… Expand
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These in vitro studies demonstrated the principal feasibility of using various human cell types isolated from fetal sources for cardiovascular tissue engineering and showed promising potential for the clinical realization of this congenital tissue engineering approach. Expand
Prenatally Fabricated Autologous Human Living Heart Valves Based on Amniotic Fluid–Derived Progenitor Cells as Single Cell Source
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The use of amniotic fluid as single cell source is a promising low-risk approach enabling the prenatal fabrication of heart valves ready to use at birth and may realize the early repair of congenital malformations. Expand
Human prenatal progenitors for pediatric cardiovascular tissue engineering
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Prenatal progenitors from different sources were successfully used for the in vitro fabrication and maturation of living autologous cardiovascular constructs and enables the prenatal fabrication of cardiovascular replacements based on a single cell source ready to use at birth. Expand
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The presented approach may serve as an experimental basis for future human prenatal cardiac interventions using fully biodegradable autologous cell-based living materials and showed in vivo functionality with intact valvular integrity and absence of thrombus formation. Expand
Amniotic Fluid-Derived Cells: An Autologous Cell Source for Cardiovascular Tissue Engineering
TLDR
Amniotic fluid-derived stem cells have shown to generate living autologous heart valve leaflets in vitro with a functional endothelial layer and mechanical properties comparable to the native heart leaflets, and represents a promising fetal cell source for potential future therapeutic applications. Expand
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A novel concept is provided demonstrating that heart valve tissue engineering based on a minimally invasive technique for both cell harvest and valve delivery as a one-step intervention is feasible in non-human primates and may overcome the limitations of contemporary surgical and interventional bioprosthetic heart valve prostheses. Expand
Umbilical cord cells as a source of cardiovascular tissue engineering
TLDR
The role of progenitor cells (mesenchymal, endothelial, prenatal) for the use in cardiovascular tissue engineering, i.e., the formation of large vessels and heart valves from umbilical cord cells is described. Expand
Amniotic fluid-derived stem cells for cardiovascular tissue engineering applications.
TLDR
Several tissue engineering and regenerative therapeutic approaches for the use of AFSC in heart patches, injection after myocardial infarction, heart valves, vascularized scaffolds, and blood vessels show great promise in the treatment of congenital cardiovascular defects. Expand
Stem cells for heart valve regeneration.
TLDR
Different stem cell sources with particular regard to cellular phenotypes and their suitability for application in heart valve tissue engineering are reviewed. Expand
Adipose derived tissue engineered heart valve
Abstract Introduction: A major challenge associated with heart valve tissue engineering is the in vitro creation of mature tissue structures compliant with native valve functionality. Various cellExpand
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