Lives and times of nuclear receptors.

@article{Alarid2006LivesAT,
  title={Lives and times of nuclear receptors.},
  author={Elaine T. Alarid},
  journal={Molecular endocrinology},
  year={2006},
  volume={20 9},
  pages={1972-81}
}
Down-regulation of receptor in response to ligand was one of the earliest functional readouts of steroid hormone action. The loss of total receptor content upon stimulation, referred to initially as receptor "processing," was carefully described with respect to receptor nuclear transformation or tight nuclear binding. It was these early studies that were the first to note a correlation between receptor turnover and induction of gene transcription, leading to the proposal that down-regulation of… CONTINUE READING