Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.


BACKGROUND Hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity. However, this compensation fails in obese with metabolic abnormalities, such as diabetes. To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA… (More)
DOI: 10.1007/s11695-011-0524-9


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