Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.

@article{Kennedy2014LiverTP,
  title={Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.},
  author={Gregory D. Kennedy and Manabu Nukaya and Susan M. Moran and Edward A. Glover and Samuel E. Weinberg and Silvia Balbo and Stephen S Hecht and Henry C. Pitot and Norman R. Drinkwater and Christopher A. Bradfield},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2014},
  volume={140 1},
  pages={
          135-43
        }
}
We set out to better understand the signal transduction pathways that mediate liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxn ("dioxin"). To this end, we first employed congenic mice homozygous for either the Ahr(b1) or Ahr(d) alleles (encoding an aryl hydrocarbon receptor (AHR) with high or low binding affinity for dioxin, respectively) and demonstrated that hepatocellular tumor promotion in response to dioxin segregated with the Ahr locus. Once we had genetic evidence for the… CONTINUE READING
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Statistical Problems in Genetics and Molecular Biology, pp. 89–163

  • N. R. Drinkwater, C. Denniston
  • CreatSpace Independent Publishing Platform
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