Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients: a multi-center experience in Shanghai, China

  title={Liver transplantation outcomes in 1,078 hepatocellular carcinoma patients: a multi-center experience in Shanghai, China},
  author={Jia Fan and Guang-shun Yang and Zhi-ren Fu and Zhi-Hai Peng and Q. Xia and Chen-hong Peng and Jian-ming Qian and Jian Zhou and Yang Xu and Shuangjian Qiu and Lin Zhong and Guangli Zhou and Jian-jun Zhang},
  journal={Journal of Cancer Research and Clinical Oncology},
PurposeTo evaluate current selection criteria for patients undergoing liver transplantation (LT) in response to hepatocellular carcinoma (HCC), and to analyze the prognostic factors for successful transplantation.MethodsWe evaluated the outcome of 1,078 consecutive patients with HCC from the Shanghai Multi-Center Collaborative LT Group who underwent LT over a 6-year period. Clinicopathologic data for these patients were evaluated. The prognostic significance was assessed using Kaplan–Meier… 
Prognosis of Liver Transplantation for Hepatocellular Carcinoma in Terms of Different Criteria: A Single Center Experience
A program to analyze and prove that the Milan criteria can be expanded safely and effectively and the Hangzhou criteria can safely expand the scope of liver transplantation for HCC to a certain extent is developed.
Liver transplantation for hepatocellular carcinoma exceeding the Milan criteria: a single-center experience
The new grading system was proved to be a promising system in predicting the patient prognosis after LT for HCC exceeding Milan criteria, and both of overall survival and RFS correlated well with the risk index grade.
Prediction of Early Recurrence of Hepatocellular Carcinoma in Patients with Cirrhosis Who Had Received Deceased Donor Liver Transplantation: A Multicenter Study
For the prediction of early recurrence of HCC in patients with cirrhosis after liver transplantation, Milan criteria, Hangzhou criteria, and AFP model-based criteria are effective predictive tools for stratification of patients into low- and high-risk groups of recurrence with different prognoses.
Comparison between Milan and UCSF criteria for liver transplantation in patients with hepatocellular carcinoma: a systematic review and meta-analysis.
Both the Milan and UCSF criteria for liver transplantation have equivalent survival rate, and a less restrictive method would not result in a great loss in the final overall survival rate and would benefit a greater number of patients.
Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation.
MHCAT can effectively predict long-term survival for HCC patients, but needs to be verified by multi-center retrospective or randomized controlled trials.
"Metroticket" predictor for assessing liver transplantation to treat hepatocellular carcinoma: a single-center analysis in mainland China.
The Metroticket model can be used to accurately predict survival in HCC-related LT cases with an absence of macrovascular invasion using a large cohort of liver transplantation (LT) patients with hepatocellular carcinoma in China.
Hangzhou criteria for liver transplantation in hepatocellular carcinoma: a single-center experience
The Hangzhou criteria should be accepted as the inclusion criteria for LT in HCC with respect to the Milan criteria and are associated with a considerable long-term outcome.
Do We Need to Be Limited by Matching Milan Criteria for Survival in Living Donor Liver Transplantation?
There is no ideal marker or an extended criterion for selecting patients with HCC beyond the Milan criteria and it needs further research to find an effective biomarker that has prognostic significance to select patients with advanced tumors.


Liver Transplantation for Hepatocellular Carcinoma: Hangzhou Experiences
The results of this study show a reliable and feasible candidates selection and prognostic criteria of LT in HCC patients and establish a new set of criteria for patient Selection and prognosis prediction.
[Indication of liver transplantation for hepatocellular carcinoma: Shanghai Fudan Criteria].
Shanghai Fudan Criteria, which expanded the tumor size limits, does not adversely impact survival of HCC patients after LT, but more patients using Shanghai FudAn Criteria could undergo liver transplantation.
Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: A report from the International Registry of Hepatic Tumors in Liver Transplantation
Current criteria for selecting tumor patients for LT may be too restrictive and could be expanded, according to data in the International Registry of Hepatic Tumors in Liver Transplantation from 1,206 patients with HCC.
Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival
The current criteria for OLT based on tumor size may be modestly expanded while still preserving excellent survival after OLT, and only pT4 stage and total tumor diameter remained statistically significant in multivariate analysis.
Extended Indication for Living Donor Liver Transplantation in Patients With Hepatocellular Carcinoma
Background. Liver transplantation is an accepted treatment option for patients with otherwise untreatable hepatocellular carcinoma (HCC). The present study assessed the outcome of living donor liver
Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria
It is suggested that UCSF criteria better predict acceptable posttransplant outcome than Milan criteria, which require information on microvascular invasion that is difficult to ascertain preoperatively without the attendant risk of biopsy.
Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA
This largest single institution experience with OLT for HCC demonstrates prolonged survival after liver transplantation for tumors beyond Milan criteria but within UCSF criteria, both when classified by preoperative imaging and by explant pathology.
Outcome after liver transplantation in patients with cirrhosis and hepatocellular carcinoma.
Liver transplantation for hepatocellular cancer: should the current indication criteria be changed?
  • L. Carlis, A. Giacomoni, D. Forti
  • Medicine
    Transplant international : official journal of the European Society for Organ Transplantation
  • 2003
A strict selection should be made to optimize graft allocation while size and multifocality should probably no longer be considered a contraindication for LTx.