Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability.

@article{Bhandari2001LiverTE,
  title={Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability.},
  author={Rena N Bhandari and L A Riccalton and Andrew L Lewis and Jeffrey R. Fry and Asya Hammond and Saul J. B. Tendler and Kevin M. Shakesheff},
  journal={Tissue engineering},
  year={2001},
  volume={7 3},
  pages={345-57}
}
A major limitation in the construction of a functional engineered liver is the short-term survival and rapid de-differentiation of hepatocytes in culture. Heterotypic cell-cell interactions may have a role to play in modulating long-term hepatocyte behavior in engineered tissues. We describe the potential of 3T3 fibroblast cells in a co-culture system to modulate function and viability of primary isolated rat hepatocytes. Over an 18-day period after isolation, hepatocytes in pure culture… CONTINUE READING
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