Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.

@article{Lan2006LivertargetedAP,
  title={Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis.},
  author={Ruth Y Z Lan and Chunmei Cheng and Zhe-xiong Lian and Koichi Tsuneyama and Guo-xiang Yang and Yuki Moritoki and Y. H. Chuang and Takafumi Nakamura and Shigeru Saito and Shinji Shimoda and Atsushi Tanaka and Christopher L Bowlus and Yasuo Takano and Aftab A Ansari and Ross L Coppel and M Eric Gershwin},
  journal={Hepatology},
  year={2006},
  volume={43 4},
  pages={729-37}
}
CD4+CD25high regulatory T cells (Tregs) play a critical role in self-tolerance, as seen in murine autoimmunity. Studies on Tregs in human autoimmunity have focused primarily on peripheral blood samples. A study targeting diseased tissue should identify direct relationships between Tregs and autoimmunity. Peripheral blood samples were collected from 91 patients with primary biliary cirrhosis (PBC), 28 immediate relatives, and 41 healthy controls, and Treg frequencies were determined as a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 107 extracted citations

Similar Papers

Loading similar papers…