Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome.

Abstract

BACKGROUND/AIMS RNA interference has considerable therapeutic potential, particularly for anti-viral therapy. We previously reported that hepatitis C virus (HCV)-directed small interfering RNA (siRNA; siE) efficiently inhibits HCV replication, using HCV replicon cells. To employ the siRNA as a therapeutic strategy, we attempted in vivo silencing of… (More)

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