Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance.

@article{Bae2012LiverspecificPS,
  title={Liver-specific p70 S6 kinase depletion protects against hepatic steatosis and systemic insulin resistance.},
  author={Eun Ju Bae and Jianfeng Xu and Da Young Oh and Gautam Kumar Bandyopadhyay and William Stacy Lagakos and Malik M. Keshwani and Jerrold M. Olefsky},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 22},
  pages={18769-80}
}
Obesity-associated hepatic steatosis is a manifestation of selective insulin resistance whereby lipogenesis remains sensitive to insulin but the ability of insulin to suppress glucose production is impaired. We created a mouse model of liver-specific knockdown of p70 S6 kinase (S6K) (L-S6K-KD) by systemic delivery of an adeno-associated virus carrying a… CONTINUE READING