Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.

Abstract

Genetic ablation of CuZn-superoxide dismutase (Sod1) in mice (Sod1(-/-) mice) leads to shortened lifespan with a dramatic increase in hepatocellular carcinoma and accelerated aging phenotypes, including early onset sarcopenia. To study the tissue specific effects of oxidative stress in the Sod1(-/-) mice, we generated mice that only express the human SOD1… (More)
DOI: 10.1016/j.mad.2016.01.005

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Cite this paper

@article{Zhang2016LiverSE, title={Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.}, author={Yiqiang Zhang and Yuhong Liu and Michael Walsh and Alex Bokov and Yuji Ikeno and Young Chul Jang and Viviana I. P{\'e}rez and H. Van Remmen and Arlan G. Richardson}, journal={Mechanisms of ageing and development}, year={2016}, volume={154}, pages={1-8} }