Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].

@article{Stiles2004LiverspecificDO,
  title={Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected].},
  author={Bangyan L. Stiles and Ying Wang and Andreas Stahl and Sara Bassilian and Wai-Nang Paul Lee and Yoon-Jung Kim and Robert T. Sherwin and Sherin U. Devaskar and Ralf Lesche and Mark A Magnuson and Hong Wu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 7},
  pages={2082-7}
}
In the liver, insulin controls both lipid and glucose metabolism through its cell surface receptor and intracellular mediators such as phosphatidylinositol 3-kinase and serine-threonine kinase AKT. The insulin signaling pathway is further modulated by protein tyrosine phosphatase or lipid phosphatase. Here, we investigated the function of phosphatase and tension homologue deleted on chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, by targeted deletion… CONTINUE READING
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