Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.

@article{Gkretsi2008LiverspecificAO,
  title={Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly.},
  author={Vasiliki Gkretsi and Udayan M Apte and Wendy M. Mars and William C. Bowen and Jian-hua Luo and Yu Yang and Yan Ping Yu and Ann Orr and Ren{\'e} St-Arnaud and Shoukat Dedhar and Klaus H. Kaestner and Chuanyue Wu and George K Michalopoulos},
  journal={Hepatology},
  year={2008},
  volume={48 6},
  pages={1932-41}
}
UNLABELLED Hepatocyte differentiation and proliferation are greatly affected by extracellular matrix (ECM). Primary hepatocytes cultured without matrix dedifferentiate over time, but matrix overlay quickly restores differentiation. ECM also is critical in liver regeneration where ECM degradation and reconstitution are steps in the regenerative process. Integrin-linked kinase (ILK) is a cell-ECM-adhesion component implicated in cell-ECM signaling by means of integrins. We investigated the role… CONTINUE READING

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