Liver sinusoidal endothelial cells depend on mannose receptor‐mediated recruitment of lysosomal enzymes for normal degradation capacity

@article{Elvevold2008LiverSE,
  title={Liver sinusoidal endothelial cells depend on mannose receptor‐mediated recruitment of lysosomal enzymes for normal degradation capacity},
  author={Kjetil H Elvevold and Jaione Sim{\'o}n-Santamar{\'i}a and Hege Hasvold and Peter McCourt and B{\aa}rd Smedsr{\o}d and Karen Kristine S{\o}rensen},
  journal={Hepatology},
  year={2008},
  volume={48}
}
Liver sinusoidal endothelial cells (LSECs) are largely responsible for the removal of circulating lysosomal enzymes (LE) via mannose receptor (MR)‐mediated endocytosis. We hypothesized that LSECs rely on this uptake to maintain their extraordinarily high degradation capacity for other endocytosed material. Circulatory half‐life studies of 125I‐cathepsin‐D in MR knockout (MR−/−) and wild‐type mice, and endocytosis studies in LSEC cultures, showed a total dependence on the MR for effective… Expand
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