Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.

@article{Liu2013LiverSE,
  title={Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.},
  author={Biao Liu and Min Wang and Xiaowen Wang and Dianyuan Zhao and Di Liu and Jing Liu and Pei-Jer Chen and Dongliang Yang and Fuchu He and Li Tang},
  journal={Journal of immunology},
  year={2013},
  volume={190 8},
  pages={4185-95}
}
Liver sinusoidal endothelial cell lectin (LSECtin) was recently reported to suppress intrahepatic T cell immunity and to limit immune-mediated liver injury. However, its role in the outcome and pathogenesis of viral infection has not yet been elucidated. Using a mouse model infected with a hepatotropic adenovirus, we found that the absence of LSECtin led to a higher frequency of intrahepatic effector CTLs. These cells produced higher levels of antiviral cytokines and cytotoxic factors and… CONTINUE READING

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