Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.

  title={Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.},
  author={Nelson Fausto and A. Douglas Laird and E M Webber},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={9 15},
During liver regeneration quiescent hepatocytes undergo one or two rounds of replication and then return to a nonproliferative state. Growth factors regulate this process by providing both stimulatory and inhibitory signals for cell proliferation. EGF, TGF alpha, and HGF stimulate DNA synthesis in hepatocytes in vivo and in culture but the sensitivity of cultured hepatocytes to the mitogenic effects of these factors is much higher than that of quiescent hepatocytes in intact livers. We have… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 72 references

Autonomous growth in serum-free mcdi uiii and prod uct ion of hepatoie’t lu ar carcitiomas by differentiated hepatocyte lines that ove’rexpre’ss transforming growth factor alpha 1

C Wu.J., Merlino, C.. Cveklova, K.. Mosinger. B..Jr., N Fausto.
Cancer Rca • 1991
View 5 Excerpts
Highly Influenced

Differential tuhuIegenic and branching morphogenetic activities of growth factelrs : lmnphieatiomisfor epimhl ’ IIal tmssue developmemst

R. Cehihamtlt, D. analJonitza.
Proc . Nail . Acrid . Sri . USA • 1995

Elevation of JUN kimsase is an early event in hepatic regemueratiomi

H. Dianionel
J Gun . lnrest . • 1995

Epidermal growth factor secreted from the salivary glattd is necessary for liver regeneration

Jones, D. E., +6 authors D. M. Miller
An,. J. Ph%aiol • 1995
View 1 Excerpt

Hepatic expression of mature transforming gmoss ’ tii factor Ill in tral , sgenic mice results iminiultiple tissue lesions

N. Sanderson, V. Factor, +4 authors S. Thorgeirsson
Proc . Nail . Amid . Sci . USA • 1995

Iiicluction of liver grosith in miornial mnlceby imifusion of hepatocyte grossth factoiJscatter factor

J. E. Meacl, L. Braums, D. A. Martin, N. anti Fausto
Ani . J . Physiol . • 1995

Placental defect and eml , ryonic lethality imsmice lacking hi ’ patocyte growth factor / scatter factor

S. C.. Bladt. F.. Coedecke, V. Brimikmann., W.. Shampe. M.. Cheramxli Zschiesche, E., C. amidBirchmneier.
Nature ( London ) • 1995

Rapid DNA binding by nuclear factor KB in hepatneytes at the stall of hirer regeneration

FitzCerald. NI., E. Webber
Mol . Cell . Bid . • 1995

Serum he ’ patoeyte growth fact , , r fe ’ vels in I yen diseases : il inii ’ al imtdicatioiis

J.-i. Okaiio, Kawasaki. It.

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