Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study.

@article{Laconi1999LiverRI,
  title={Liver regeneration in response to partial hepatectomy in rats treated with retrorsine: a kinetic study.},
  author={Sergio Laconi and Francesca Curreli and S. Christobel Diana and Daniela Pasciu and Gianpaolo De Filippo and Dittakavi S. R. Sarma and Paolo Pani and Ezio Laconi},
  journal={Journal of hepatology},
  year={1999},
  volume={31 6},
  pages={1069-74}
}
BACKGROUND/AIM We have designed an experimental model in which transplantation of normal hepatocytes into rats previously treated with retrorsine (a naturally-occurring pyrrolizidine alkaloid) results in near-complete replacement of the recipient liver by donor-derived cells. Two/thirds partial hepatectomy was found to be essential for this process to occur. To probe this finding, in the present study we describe the kinetics of liver regeneration in response to partial hepatectomy in rats… CONTINUE READING