Liver regeneration and alpha-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation.

@article{Dabeva1998LiverRA,
  title={Liver regeneration and alpha-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation.},
  author={Mariana D. Dabeva and Ezio Laconi and Ran Oren and Petko M. Petkov and E Hurston and David A. Shafritz},
  journal={Cancer research},
  year={1998},
  volume={58 24},
  pages={5825-34}
}
Recently, we described a new model for hepatocyte transplantation with nearly total replacement of the liver by exogenous hepatocytes (E. Laconi et al., Am. J. Pathol., 153: 319-329, 1998). The model is based on the mitoinhibitory effect of the pyrrolizidine alkaloid retrorsine on hepatocytes in the resident liver while transplanted hepatocytes proliferate. In this study, we exploit this novel approach to address the important and controversial issue of whether hepatocytes, when proliferating… CONTINUE READING
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