Liver receptor homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells.

@article{Yazawa2009LiverRH,
  title={Liver receptor homolog-1 regulates the transcription of steroidogenic enzymes and induces the differentiation of mesenchymal stem cells into steroidogenic cells.},
  author={Takashi Yazawa and Yoshihiko Inanoka and Tetsuya Mizutani and Mayu Kuribayashi and Akihiro Umezawa and Kaoru Miyamoto},
  journal={Endocrinology},
  year={2009},
  volume={150 8},
  pages={3885-93}
}
Steroidogenic factor-1 (SF-1, also known as Ad4BP) has been demonstrated to be a primary transcriptional regulator of steroidogenic-related genes. However, mRNA for liver receptor homolog-1 (LRH-1), which together with SF-1, belongs to the NR5A nuclear receptor family, is expressed at much higher levels than SF-1 mRNA in the human gonad. In our previous studies, we demonstrated that SF-1 induced the differentiation of bone marrow-derived mesenchymal stem cells (MSCs) into steroidogenic cells… CONTINUE READING