Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity.

  title={Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity.},
  author={Jan B{\"o}ttcher and Oliver Schanz and Dirk Wohlleber and Zeinab F. Abdullah and Svenja Debey-Pascher and Andrea Staratschek-Jox and Bastian Hoechst and Silke I Hegenbarth and Jessica Grell and Andreas Limmer and Imke Atreya and Markus F Neurath and Dirk H Busch and Edgar Schmitt and Peter van Endert and Waldemar Kolanus and Christian Kurts and Joachim L. Schultze and Linda Diehl and Percy A Knolle},
  journal={Cell reports},
  volume={3 3},
Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells… CONTINUE READING
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