Liver pathology in compound heterozygous patients for hemochromatosis mutations.

@article{SchnigerHekele2002LiverPI,
  title={Liver pathology in compound heterozygous patients for hemochromatosis mutations.},
  author={Maximilian Sch{\"o}niger-Hekele and Christian M{\"u}ller and Cl{\`a}udia Danella Polli and Friedrich Wrba and Edward Penner and Peter Ferenci},
  journal={Liver},
  year={2002},
  volume={22 4},
  pages={
          295-301
        }
}
BACKGROUND While hepatic pathology of homozygous carriers of the C282Y mutation of the HFE haemochromatosis gene is well defined, the impact of the C282Y/H63D compound heterozygous carrier state is unknown. AIMS To evaluate the range of hepatic pathology in C282Y/H63D compound heterozygous patients. PATIENTS 25 C282Y/H63D compound heterozygous patients with and without known underlying liver disease underwent liver biopsies for evaluation or abnormal liver tests. Eleven cadaveric liver… CONTINUE READING