Liver organogenesis promoted by endothelial cells prior to vascular function.

@article{Matsumoto2001LiverOP,
  title={Liver organogenesis promoted by endothelial cells prior to vascular function.},
  author={Kazue Matsumoto and Hideyuki Yoshitomi and Janet Rossant and Kenneth S Zaret},
  journal={Science},
  year={2001},
  volume={294 5542},
  pages={559-63}
}
The embryonic role of endothelial cells and nascent vessels in promoting organogenesis, prior to vascular function, is unclear. We find that early endothelial cells in mouse embryos surround newly specified hepatic endoderm and delimit the mesenchymal domain into which the liver bud grows. In flk-1 mutant embryos, which lack endothelial cells, hepatic specification occurs, but liver morphogenesis fails prior to mesenchyme invasion. We developed an embryo tissue explant system that permits liver… CONTINUE READING
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