Liver metabolism of porphyrins and haem

@article{Bloomer1998LiverMO,
  title={Liver metabolism of porphyrins and haem},
  author={J. Bloomer},
  journal={Journal of Gastroenterology and Hepatology},
  year={1998},
  volume={13}
}
  • J. Bloomer
  • Published 1998
  • Medicine
  • Journal of Gastroenterology and Hepatology
The liver is an active site for the biosynthesis of haem and porphyrinogens/porphyrins, which are intermediates of the haem biosynthetic pathway, because haem is required for functional activity of the cytochrome P 450 system and other critical hepatic haemoproteins. The production of hepatic haem is regulated primarily through the activity of aminolaevulinic acid synthase which is the first and normally rate‐limiting enzyme of the pathway. This is, in turn, controlled by a putative regulatory… Expand
23 Citations
Erythrocyte protoporphyrins in hepatitis C viral infection.
  • 10
N-alkylprotoporphyrin formation and hepatic porphyria in dogs after administration of a new antiepileptic drug candidate: mechanism and species specificity.
  • 5
  • PDF
Drug-Induced Protoporphyria in Beagle Dogs
  • 10
Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress*
  • 12
  • Highly Influenced
  • PDF
Serum and Hepatic Autofluorescence as a Real-Time Diagnostic Tool for Early Cholestasis Assessment
  • 2
  • PDF
The role of HNF-1alpha in controlling hepatic catalase activity.
  • 8
The Role of HNF-1 a in Controlling Hepatic Catalase Activity
  • 10
  • Highly Influenced
  • PDF
...
1
2
3
...

References

SHOWING 1-10 OF 43 REFERENCES
Effects of haem infusion on biliary secretion of porphyrins, haem and bilirubin in man
  • 17
Hepatic heme metabolism and cytochrome P450 in cirrhotic rat liver.
  • 20
Haem arginate improves hepatic oxidative metabolism in variegate porphyria.
  • 16
Rapid normalization of antipyrine oxidation by heme in variegate porphyria
  • 15
Secretion of haem by hepatic parenchymal cells.
  • 9
...
1
2
3
4
5
...