Liver metabolism of porphyrins and haem

@article{Bloomer1998LiverMO,
  title={Liver metabolism of porphyrins and haem},
  author={J. Bloomer},
  journal={Journal of Gastroenterology and Hepatology},
  year={1998},
  volume={13}
}
  • J. Bloomer
  • Published 1998
  • Medicine
  • Journal of Gastroenterology and Hepatology
The liver is an active site for the biosynthesis of haem and porphyrinogens/porphyrins, which are intermediates of the haem biosynthetic pathway, because haem is required for functional activity of the cytochrome P 450 system and other critical hepatic haemoproteins. The production of hepatic haem is regulated primarily through the activity of aminolaevulinic acid synthase which is the first and normally rate‐limiting enzyme of the pathway. This is, in turn, controlled by a putative regulatory… Expand
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