Contribution of Gut Bacteria to Liver Pathobiology
BACKGROUND/AIM The aim of the study was to evaluate histological liver lesions and to compare these with the results of biochemical parametres. METHODOLOGY An experimental model of chronic ulcerative colitis in rats was utilized. RESULTS Histological studies of the biliary tree showed progressive fibrotic inflammation which fulfilled the criteria of early sclerosing cholangitis. The biochemical tests of liver function were, however normal in all animals. CONCLUSIONS Sclerosing cholangitis in experimental ulcerative colitis is a progressive disease, and normal liver biochemistry does not exclude changes in liver histology.