Liver-homing of purified glucose oxidase: a novel in vivo model of physiological hepatic oxidative stress (H2O2).


BACKGROUND/AIMS Reactive oxygen species (ROS), such as H2O2, are implicated in normal and pathological liver function. However, due to the lack of suitable in vivo models of ROS generation the (patho) physiological relevance of H2O2 remains controversial. METHODS We established a novel model of sustained hepatic H2O2 release using intravenous… (More)


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