Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.

@article{Gaskill2005LiverHA,
  title={Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.},
  author={Cynthia L Gaskill and Lewis McCoy Miller and John S. Mattoon and Walter E. Hoffmann and Shelley A. Burton and H C J Gelens and Sherri L. Ihle and J Brand Miller and Darcy H Shaw and Alastair E Cribb},
  journal={Veterinary pathology},
  year={2005},
  volume={42 2},
  pages={147-60}
}
Phenobarbital (PB) therapy is frequently associated with elevated serum alanine aminotransferase (ALT) and alkaline phosphatase (AP) activities in dogs without clinical signs of liver disease. The goal of this study was to determine if increased serum ALT and AP activities in clinically healthy PB-treated epileptic dogs are due to hepatic enzyme induction or to subclinical liver injury. Liver biopsies were obtained from 12 PB-treated dogs without clinical signs of liver disease but with… CONTINUE READING
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