Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.

@article{Aloia2006LiverHA,
  title={Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.},
  author={Thomas A Aloia and Myl{\`e}ne Sebagh and Maryl{\'e}ne Plasse and Vincent Karam and Francis L{\'e}vi and Sylvie Giacchetti and Daniel Azoulay and Henri Bismuth and Denis Castaing and Ren{\'e} Adam},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 31},
  pages={4983-90}
}
PURPOSE Preoperative chemotherapy for colorectal liver metastases (CLM) can produce histologic changes in the nontumor-bearing liver (NTBL) that may impact on surgical outcomes. PATIENTS AND METHODS From a cohort of 303 patients treated for CLM with liver resection, 92 patients (75 received preoperative chemotherapy: group C+; and 17 were chemotherapy naïve: group C-) were randomly selected for detailed pathologic analysis. Preoperative chemotherapy consisted of fluorouracil (FU)/leucovorin… CONTINUE READING
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