Liver granulomatosis: a case of Chlamydophila pneumoniae infection.


An 18-year-old man was referred to the Internal Medicine ward because of a 2-week history of intermittent high fever, weight loss and cough. Clinical examination revealed hepato-splenomegaly and multiple lymph nodes swelling while laboratory tests showed elevated C-reactive protein, gamma glutamyl transferase and lactate dehydrogenase. All serologic testes for auto-immune antibodies, viruses and bacteria were negative except for Chlamydophila pneumoniae. An 18-FDG PET computed tomography scanner showed hypermetabolism in the liver, spleen and lymph nodes. We therefore conducted a liver biopsy that demonstrated non-necrotizing granulomas. We conclude to a C. pneumoniae infection associated with a granulomatous hepatitis. After treatment with Doxyciclin the patient had no more fever, hepatosplenomegaly resolved and blood testes normalized. This case report is to our knowledge the first report of a granulomatous hepatitis associated with C. pneumoniae respiratory infection.

DOI: 10.1179/2295333714Y.0000000068

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@article{Yildiz2015LiverGA, title={Liver granulomatosis: a case of Chlamydophila pneumoniae infection.}, author={Halil Yildiz and Gr{\'e}goire Wie{\"{e}rs and Jean cyr Yombi and J C Marot}, journal={Acta clinica Belgica}, year={2015}, volume={70 1}, pages={50-2} }