Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells.

@article{Pommey2013LiverGF,
  title={Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells.},
  author={Sandra A Pommey and Bo Lu and Jennifer L. McRae and J. P. Stagg and Prue Hill and Evelyn J Salvaris and Simon Christopher Robson and Anthony J. F. d'Apice and Peter J Cowan and Karen M Dwyer},
  journal={Hepatology},
  year={2013},
  volume={57 4},
  pages={
          1597-606
        }
}
UNLABELLED Ischemia-reperfusion injury (IRI) is a major limiting event for successful liver transplantation, and CD4+ T cells and invariant natural killer T (iNKT) cells have been implicated in promoting IRI. We hypothesized that hepatic overexpression of CD39, an ectonucleotidase with antiinflammatory functions, will protect liver grafts after prolonged cold ischemia. CD39-transgenic (CD39tg) and wildtype (WT) mouse livers were transplanted into WT recipients after 18 hours cold storage and… CONTINUE READING
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