Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?

@article{AzzoutMarniche2007LiverGA,
  title={Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats?},
  author={Dalila Azzout-Marniche and Claire Gaudichon and Cl{\'e}mence Blouet and C. Ulrike Bos and V{\'e}ronique Math{\'e} and Jean-François Huneau and Daniel Tom{\'e}},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={292 4},
  pages={R1400-7}
}
This paper provides molecular evidence for a liver glyconeogenic pathway, that is, a concomitant activation of hepatic gluconeogenesis and glycogenesis, which could participate in the mechanisms that cope with amino acid excess in high-protein (HP) fed rats. This evidence is based on the concomitant upregulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression, downregulation of glucose 6-phosphatase catalytic subunit (G6PC1) gene expression, an absence of glucose release from… CONTINUE READING