Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C.

@article{Asselah2008LiverGE,
  title={Liver gene expression signature to predict response to pegylated interferon plus ribavirin combination therapy in patients with chronic hepatitis C.},
  author={Tarik Asselah and Ivan Bi{\'e}che and S Narguet and Abdullah Sabbagh and Ingrid Laurendeau and M-P Ripault and Nathalie Boyer and Michelle Martinot-Peignoux and D. Valla and Michel Vidaud and Patrick Marcellin},
  journal={Gut},
  year={2008},
  volume={57 4},
  pages={516-24}
}
BACKGROUND AND AIMS The gold standard treatment of chronic hepatitis C (CHC) is combined pegylated interferon and ribavirin. Considering side effects and treatment cost, prediction of treatment response before therapy is important. The aim of this study was to identify a liver gene signature to predict sustained virological response in patients with CHC. METHODS Group A (training set) comprised 40 patients with CHC including 14 non-responders (NRs) and 26 sustained virological responders… CONTINUE READING

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