Liver functional genomics in beef cows on grazing systems: novel genes and pathways revealed.
@article{Laporta2014LiverFG,
title={Liver functional genomics in beef cows on grazing systems: novel genes and pathways revealed.},
author={Jimena Laporta and Guilherme J. M. Rosa and Hugo Naya and Mariana Carriquiry},
journal={Physiological genomics},
year={2014},
volume={46 4},
pages={
138-47
}
}The adaptation of the liver to periods of negative energy balance is largely unknown in beef cattle on grazing systems. We evaluated liver transcriptome throughout gestation and early lactation of purebred and crossbred beef cows [Angus, Hereford, and their F1 crossbreeds (CR)], grazing high or low herbage allowances (HA) of native grasslands (4 and 2.5 kg dry matter/kg body wt annual mean; n = 16) using an Agilent 4 × 44k bovine array. A total of 4,661 transcripts were affected by days [272…
9 Citations
Changes in body composition during the winter gestation period in mature beef cows grazing different herbage allowances of native grasslands
- Biology
- 2017
It is suggested that HI maintained greater body condition score and retained gross energy content when compared with LO cows, and CG affected not only body composition but also composition of mobilised/retained weight during the winter gestation period with a greater protein tissue mobilisation in CR than PU cows.
Hepatic transcriptome profile of sheep (Ovis aries) in response to overgrazing: novel genes and pathways revealed
- BiologyBMC Genetics
- 2019
BackgroundOvergrazing is a major factor that causes steppe degradation in Inner Mongolian, resulting in extensive ecosystem damage. Scarcity of grass means sheep are smaller and therefore mutton and…
Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes.
- Biology, MedicineJournal of animal science
- 2018
High-efficiency steers (low-RFI) probably had greater efficiency in hepatic nutrient metabolism, which was strongly associated with greater hepatic mitochondrial density and functioning, mainly of mitochondrial complex II.
Overgrazing induces alterations in the hepatic proteome of sheep (Ovis aries): an iTRAQ-based quantitative proteomic analysis
- BiologyProteome Science
- 2016
Results suggest that the reductions in animal growth induced by overgrazing are associated with liver proteomic changes, especially the proteins involved in nitrogen compounds metabolism and immunity.
Transcriptomic analysis of skeletal muscle from beef cattle exposed to illicit schedules containing dexamethasone: identification of new candidate biomarkers and their validation using samples from a field monitoring trial
- BiologyFood additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment
- 2015
This study provides some interesting glucocorticoid-responsive biomarkers whose expression was contradictory to what is reported in human studies and points out the transcriptomic signature dissimilarity between commercial and experimentally treated animals.
STAT6, PBX2, and PBRM1 Emerge as Predicted Regulators of 452 Differentially Expressed Genes Associated With Puberty in Brahman Heifers
- BiologyFront. Genet.
- 2018
Transcriptomic analyses to liver samples of pre- and post-pubertal Brahman heifers identified differentially expressed (DE) genes and genes encoding transcription factors (TFs) and suggested potential biological mechanisms and pathways linking liver function to puberty.
Transcriptomic and Metabolomic Analyses Reveal Inhibition of Hepatic Adipogenesis and Fat Catabolism in Yak for Adaptation to Forage Shortage During Cold Season
- BiologyFrontiers in Cell and Developmental Biology
- 2021
Integrative analysis of the transcriptome and metabolome demonstrated that glycolysis or gluconeogenesis, PPAR signaling pathway, fatty acid biosynthesis, steroid biosynthesis and glutathione metabolism play an important role in the potential relationship between differential expression genes and metabolites.
References
SHOWING 1-10 OF 54 REFERENCES
Plane of nutrition prepartum alters hepatic gene expression and function in dairy cows as assessed by longitudinal transcript and metabolic profiling.
- Biology, MedicinePhysiological genomics
- 2006
Overall, data show that moderate overfeeding of energy in the dry period results in transcriptional changes predisposing cows to fatty liver and perhaps compromising overall liver health during the periparturient period, and controlled energy intake may confer an advantage to the cow by triggering hepatic molecular adaptations well ahead of parturition.
Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function.
- Biology, MedicinePhysiological genomics
- 2005
A model for integrating gene expression, metabolite, and Liver composition data to explain physiological events in placenta, adipose, and liver during the periparturient period is proposed and results provide evidence that hepatic inflammatory responses occurring near parturition initiate or augment adipose catabolism.
Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach
- Biology, MedicinePhysiological genomics
- 2010
In high-yielding dairy cows the liver undergoes extensive physiological and biochemical changes during the early postpartum period in an effort to re-establish metabolic homeostasis and to counteract…
Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows.
- Biology, MedicinePhysiological genomics
- 2007
Feed restriction and ketosis resulted in previously unrecognized alterations in gene network expression underlying key cellular functions and discrete metabolic events that might help explain well-documented physiological adaptations to reduced feed intake in early postpartum cows and, thus, provide molecular targets that might be useful in prevention and treatment of liver lipidosis andketosis.
Feed restriction, but not l-carnitine infusion, alters the liver transcriptome by inhibiting sterol synthesis and mitochondrial oxidative phosphorylation and increasing gluconeogenesis in mid-lactation dairy cows.
- Biology, MedicineJournal of dairy science
- 2013
Results from the bioinformatics functional analysis of genes affected by DMI restriction uncovered biosynthesis of cholesterol and energy generation by mitochondrial respiration as the most relevant and inhibited functions and indicated an increase of flux toward gluconeogenesis.
Tissue-specific mRNA expression patterns reveal a coordinated metabolic response associated with genetic selection for milk production in cows.
- Biology, MedicinePhysiological genomics
- 2012
Correlations of mRNA expression levels to milk performance traits indicate that gene transcriptional processes may play a regulatory role in liver, mammary gland, and skeletal muscle to enable cows with different genetic potential for milk performance to cope with metabolic lactation-associated challenges.
Relationship of polymorphisms within metabolic genes and carcass traits in crossbred beef cattle.
- Biology, MedicineJournal of animal science
- 2012
Data from this study indicate that polymorphisms within candidate genes have an indirect relationship with lipogenesis, and it will be necessary to establish if these markers will be successful as predictors of fatness components and carcass traits in cattle.
Variation in hepatic regulation of metabolism during the dry period and in early lactation in dairy cows.
- Biology, MedicineJournal of dairy science
- 2009
Investigation of variations in hepatic regulation of metabolism during the dry period, after parturition, and in early lactation in dairy cows found metabolic regulation differs between cows, indicating that metabolic regulation in cows is a dynamic system.
Hepatic gene expression in multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation.
- Biology, MedicineJournal of dairy science
- 2009
It is indicated that bST induced increases in hepatic expression of GHR, IGF-I, and IGFBP3 when cows were in negative energy balance in early lactation, and there was support for a potential homeorhetic role of hepatic FGF-21 via uncoupling the somatotropin-IGF-axis inEarly lactation.
Adaptations of Glucose and Long-Chain Fatty Acid Metabolism in Liver of Dairy Cows during the Periparturient Period
- Biology
- 2001
Techniques of modern biochemistry promise to further understanding of the mechanisms of metabolic adaptation during the peripartal period, and to quantify the effects of nutrition and environment during pre- and postpartum periods on hepatic glucose and lipid metabolism.





