Liver from bone marrow in humans

@article{Theise2000LiverFB,
  title={Liver from bone marrow in humans},
  author={Neil D. Theise and Manjunath A. Nimmakayalu and Rebekah Gardner and Peter B. Illei and Glyn R. Morgan and Lewis W. Teperman and Octavian Henegariu and Diane S. Krause},
  journal={Hepatology},
  year={2000},
  volume={32}
}
It has been shown in animal models that hepatocytes and cholangiocytes can derive from bone marrow cells. We have investigated whether such a process occurs in humans. Archival autopsy and biopsy liver specimens were obtained from 2 female recipients of therapeutic bone marrow transplantations with male donors and from 4 male recipients of orthotopic liver transplantations from female donors. Immunohistochemical staining with monoclonal antibody CAM5.2, specific for cytokeratins 8, 18, and 19… 
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Liver biopsies from human females contain male hepatocytes in the absence of transplantation
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In both studies, female bone marrow transplant recipients receiving male donor cells and males transplanted with female donor livers were examined; the fate of the donor marrow derived cells and the host haematopoietic stem cells in the latter were followed by identifying male derived cells in histological sections of livers using molecular probes specific for the Y chromosome.
Commitment of bone marrow cells to hepatic stellate cells in mouse.
Bone marrow contributes to renal parenchymal turnover and regeneration
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The presence of bone marrow‐derived cells was noted in both histologically normal mouse kidneys and in human transplanted kidneys suffering damage from a variety of causes, indicating that bone marrow cells contribute to both normal turnover of renal epithelia and regeneration after damage, and is suggested that this could be exploited therapeutically.
Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells.
TLDR
All six recipients of sex-mismatched transplants showed evidence of complete hematopoietic donor chimerism and the presence of donor cells in the biopsy specimens did not seem to depend on the intensity of tissue damage induced by graft-versus-host disease.
Bone marrow stem cells contribute to alcohol liver fibrosis in humans.
Bone marrow-derived stem cell (BMSC) contribution to liver repair varies considerably and recent evidence suggests these cells may contribute to liver fibrosis. We investigated the mobilization and…
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The data indicate that bone marrow cells contribute to the regeneration of intestinal myofibroblasts and epithelium after damage, and it is suggested that this could be exploited therapeutically.
Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/γcnull mice through cell fusion
TLDR
Results show that human CD34+ cells fuse with hepatocytes of NOG mice without liver injury, lose their hematopoietic phenotype, and begin hepatocyte‐specific gene transcription, phenomena that were not observed when CD34− cells were transplanted.
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