Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation.

@article{Venugopal2010LiverFC,
  title={Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation.},
  author={Senthil Kumar Venugopal and Joy Jiang and T Kim and Yong Li and Si-Si Wang and Natalie Julia Torok and J Wu and Mark A. Zern},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2010},
  volume={298 1},
  pages={G101-6}
}
Activation of hepatic stellate cells (HSC) results in their proliferation and in the secretion of extracellular matrix (ECM) proteins, which leads to hepatic fibrosis. microRNAs (miRNAs) have been shown to regulate various cell functions, such as proliferation, differentiation, and apoptosis. Hence, we have analyzed the miRNAs that were differentially expressed in HSC isolated from sham-operated and bile duct-ligated rats. Expression of two miRNAs, miRNA-150 and miRNA-194, was reduced in HSC… CONTINUE READING

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