Liver enzyme monitoring in patients treated with troglitazone.

@article{Graham2001LiverEM,
  title={Liver enzyme monitoring in patients treated with troglitazone.},
  author={D. Graham and C. R. Drinkard and D. Shatin and Y. Tsong and M. J. Burgess},
  journal={JAMA},
  year={2001},
  volume={286 7},
  pages={
          831-3
        }
}
  • D. Graham, C. R. Drinkard, +2 authors M. J. Burgess
  • Published 2001
  • Medicine
  • JAMA
  • CONTEXT Soon after initial marketing in March 1997, troglitazone, the first thiazolidinedione antidiabetic agent, was found to cause life-threatening acute liver failure. The drug was removed from the market in March 2000. OBJECTIVE To evaluate the effect of US Food and Drug Administration (FDA) risk management efforts, including repeated labeling changes and "Dear Healthcare Professional" letters, on periodic liver enzyme monitoring of patients taking troglitazone. DESIGN, SETTING, AND… CONTINUE READING
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