Liver-enriched transcription factors and hepatocyte differentiation.

  title={Liver-enriched transcription factors and hepatocyte differentiation.},
  author={Silvia Cereghini},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={10 2},
  • Silvia Cereghini
  • Published 1996 in
    FASEB journal : official publication of the…
Liver-specific gene expression in adult hepatocytes relies on four families of evolutionary conserved transcription factors that are liver-enriched but not restricted to this tissue. These factors function in unique combinations, often synergistically, to stimulate cell-specific transcription. Each family is composed of several members displaying similar, if not identical, DNA recognition properties and sharing structural homology in their DNA binding domains. The homo- and heterodimerization… CONTINUE READING
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