Liver endothelium binds, transports, and desialates ceruloplasmin which is then recognized by galactosyl receptors of hepatocytes.

@article{Tavassoli1985LiverEB,
  title={Liver endothelium binds, transports, and desialates ceruloplasmin which is then recognized by galactosyl receptors of hepatocytes.},
  author={Mehdi Tavassoli},
  journal={Transactions of the Association of American Physicians},
  year={1985},
  volume={98},
  pages={370-7}
}
  • Mehdi Tavassoli
  • Published 1985 in
    Transactions of the Association of American…
Incubation of 125I-labeled ceruloplasmin with various fractions of liver cell suspensions at 4 degrees C led to its exclusive binding to the endothelium. At 37 degrees C the uptake was followed by internalization and subsequent release of the labeled molecule which, then, had acquired the capacity to bind to the hepatocytes. Unlabeled CP did not inhibit this hepatocyte binding, but two galactose-containing molecules, asialofetuin and asialoceruloplasmin, did. Incubation of double-labeled CP… CONTINUE READING

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