Liver disease in Egypt: Hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors

@article{Strickland2006LiverDI,
  title={Liver disease in Egypt: Hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors},
  author={G. Thomas Strickland},
  journal={Hepatology},
  year={2006},
  volume={43}
}
In Egypt, schistosomiasis was traditionally the most important public health problem and infection with Schistosoma mansoni the major cause of liver disease. From the 1950s until the 1980s, the Egyptian Ministry of Health (MOH) undertook large control campaigns using intravenous tartar emetic, the standard treatment for schistosomiasis, as community‐wide therapy. This commendable effort to control a major health problem unfortunately established a very large reservoir of hepatitis C virus (HCV… 

FROM SCHISTOSOMIASIS TO HEPATITIS C: THE SPREAD OF HCV IN EGYPT

From the 1950s to the 1980s, Egypt tried to control a schistosomiasis epidemic with a program of mass injections of tartar emetic, which spread hepatitis C to Egyptians in what is believed to be the largest iatro- genic transmission of blood-borne disease in history.

Human Schistosomiasis mansoni associated with hepatocellular carcinoma in Egypt: current perspective

Analysis of the sex distribution among the studied groups showed that HCC was more common in males than females in both groups, and as regards the aggression of HCC, it was more commonly multifocal and larger in size in Patients with concomitant infection than in patients with HCV alone.

Hepatitis C in Egypt – past, present, and future

There has been a spectrum of treatments to target the public health disaster represented by the hepatitis C problem in Egypt: from the use of PEGylated interferon to the recent use of direct acting antiviral drugs.

Current Status of Schistosomiasis in Egypt: Parasitologic and Endoscopic Study in Sharqia Governorate

A decrease in the prevalence of schistosomiasis that may be explained by the current policy of schistsomiasis control in Egypt is revealed.

The peak impact of an Egyptain outbreak of hepatitis C virus: Has it passed or has not yet occurred?

Sero-prevalence of anti-HCV among these children is significantly lower than the detected one in Tanta city in 1991, and low positive PCR in these studies was referred to the healthy children who were tested during the community surveys.

A cross sectional study of the risk factors of hepatitis C infection in North Egypt

To study the main reasons of HCV prevalence in the Egyptian Delta valley, a questionnaire-based study was conducted by members of the HCV Fighters project, and the most probable risk factors included regular visits to dental clinics and history of bilharzial infection.

Neglected tropical diseases as a cause of chronic liver disease: the case of Schistosomiasis and Hepatitis C Co‐infections in Egypt

It is found that these two co-infections and their synergies in promoting liver disease in Egypt represent an illustrative example of a burden of a CNCD in LMICs.

In Egyptians, a mutation in the lymphotoxin-α gene may increase susceptibility to hepatitis C virus but not that to schistosomal infection

The LTα mutation may have a role in susceptibility to HCV infection (and the subsequent development of clinical manifestations) but appears to have little if any effect on susceptibility to schistosome infection.

Fibroscan of chronic HCV patients coinfected with schistosomiasis.

  • G. EsmatA. Elsharkawy S. Labib
  • Medicine, Biology
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
  • 2013
...

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