Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.

  title={Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.},
  author={Abdelfattah El Ouaamari and Dan Kawamori and Ercument Dirice and Chong Wee Liew and Jennifer L. Shadrach and Jiang Wei Hu and Hitoshi Katsuta and Jennifer Hollister-Lock and Wei-Jun Qian and Amy J. Wagers and Rohit N. Kulkarni},
  journal={Cell reports},
  volume={3 2},
Integrative organ crosstalk regulates key aspects of energy homeostasis, and its dysregulation may underlie metabolic disorders such as obesity and diabetes. To test the hypothesis that crosstalk between the liver and pancreatic islets modulates β cell growth in response to insulin resistance, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique model that exhibits dramatic islet hyperplasia. Using complementary in vivo parabiosis and transplantation assays, as well as… CONTINUE READING
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