Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss.

  title={Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss.},
  author={Marie K Lindberg and Johan Svensson and Katrien Venken and Tina M. Chavoshi and Niklas Andersson and S Mov{\'e}rare Skrtic and Olle Isaksson and D Vanderschueren and Hans Carlsten and C Ohlsson},
  volume={38 1},
INTRODUCTION Estrogen deficiency results in trabecular bone loss, associated with T-cell proliferation in the bone marrow. Insulin-like growth factor I (IGF-I) is involved in the regulation of both bone metabolism and lymphopoiesis. A major part of serum IGF-I is derived from the liver. The aim of the present study was to investigate the role of liver-derived IGF-I for ovariectomy (ovx)-induced trabecular bone loss. MATERIALS AND METHODS Mice with adult liver-specific IGF-I inactivation (LI… CONTINUE READING
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