Liver damage after paracetamol overdose. Comparison of liver-function tests, fasting serum bile acids, and liver histology.

@article{James1975LiverDA,
  title={Liver damage after paracetamol overdose. Comparison of liver-function tests, fasting serum bile acids, and liver histology.},
  author={Oliver F. W. James and Milena Lesna and Seren Haf Roberts and L Pulman and Adrian P. Douglas and Peter A Smith and Alexander J Watson},
  journal={Lancet},
  year={1975},
  volume={2 7935},
  pages={579-81}
}
54 patients have been studied after paracetamol (acetaminophen) overdose. Liver-function tests and fasting serum bile-acids were measured daily; liver biopsy was done in all cases, and slides were examined "blind" to assess liver damage. The plasma-paracetamol was measured on one occasion. A histological abnormality was present in the livers of 53 of the 54 patients, and was minor in 23, moderate in 16, and severe in 14. In 6 patients with moderate and 18 with mild histological abnormality… CONTINUE READING

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