Liver cirrhosis and hepatoma in rats induced by 3-benzylsydnone-4-acetamide.

@article{Otsubo1974LiverCA,
  title={Liver cirrhosis and hepatoma in rats induced by 3-benzylsydnone-4-acetamide.},
  author={Kazuaki Otsubo and Makoto Saito},
  journal={Gan},
  year={1974},
  volume={65 3},
  pages={
          273-7
        }
}
2 Citations
EFFECTS OF DOSAGE AND SEX ON THE LIVER INJURY AND INCIDENCE OF HEPATOCELLULAR TUMORS INDUCED BY 3-BENZYLSYDNONE-4-ACETAMIDE IN RATS
TLDR
Initially BSA caused centrilobular necrosis of the liver, with elevated serum GPT activity, then appeared proliferating liver cell clusters from which adenomatous and neoplastic changes developed.
HEPATOTOXIC AND HEPATOCARCINOGENIC EFFECTS OF A SYDNONE DERIVATIVE, 3-BENZYLSYDNONE-4-ACETAMIDE, ON MICE: DIFFERENCES IN SUSCEPTIBILITY BY STRAIN AND SEX
TLDR
Hepatotoxic effect of BSA given in drinking water at concentrations up to 0.2% for 4 weeks varies considerably in differing strains of mice, DDD is the most susceptible followed by C57BL/6, DBA, BALB/c, and ICR, while C3H mice were resistant at the tested doses.