Liver cell culture toxicity and surfactant potency of erythromycin derivatives.

@article{Dujovne1975LiverCC,
  title={Liver cell culture toxicity and surfactant potency of erythromycin derivatives.},
  author={C. Dujovne},
  journal={Toxicology and applied pharmacology},
  year={1975},
  volume={32 1},
  pages={
          11-20
        }
}
  • C. Dujovne
  • Published 1975
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
Abstract When Chang liver cell cultures were exposed to a new erythromycin salt, erythromycin cetyl sulfate, and other marketed erythromycin derivatives (erythromycin base, stearate, and estolate) only the cetyl sulfate and estolate salts had cytotoxic effects. Both compounds were very active in lowering surface tension which suggests a possible relationship between this physiocochemical property and their cytotoxic potential in vitro. These in vitro results correlate with the known differences… Expand
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