Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.

@article{Min2012LiverCI,
  title={Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.},
  author={Lihua Min and Yuan Ji and Latifa Bakiri and Zhixin Qiu and Jin Cen and Xiaotao Chen and Lingli Chen and Harald Scheuch and Hai Jun Zheng and Lunxiu Qin and Kurt Zatloukal and Lijian Hui and Erwin F Wagner},
  journal={Nature cell biology},
  year={2012},
  volume={14 11},
  pages={
          1203-11
        }
}
Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation remain elusive, largely owing to a lack of suitable animal models and limited availability of human precancerous lesions. Here we show using genetic mouse models specific for liver cancer initiation, that survival of initiated cancer cells is controlled by c-Jun, independently of p53, through… CONTINUE READING
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