Liver biopsy in neonatal cholestasis: a review on statistical grounds.

  title={Liver biopsy in neonatal cholestasis: a review on statistical grounds.},
  author={Maria Cl{\'a}udia Nogueira Zerbini and Stefania Gallucci and R Maezono and Chikara Ueno and Gilda Porta and Jo{\~a}o Gilberto Maksoud and Luiz Carlos da Costa Gayotto},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  volume={10 8},
The aim of this study was to improve the accuracy of the histopathologic diagnosis in the differential diagnosis between obstructive and nonobstructive forms of neonatal cholestasis, using this clinical situation as a model for a mathematical approach. The study was blind, and we performed it in two steps. In the first step, 49 histologic parameters were visually estimated and were scored on a scale of 0 to 4+ in 100 liver biopsy specimens obtained between 1980 and 1985 from 78 patients with… CONTINUE READING


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