Liver aquaporins: significance in canalicular and ductal bile formation.

  title={Liver aquaporins: significance in canalicular and ductal bile formation.},
  author={Ra{\'u}l Alberto Marinelli and Sergio A. Gradilone and Flavia I Carreras and Giuseppe Calamita and Guillermo Luis Lehmann},
  journal={Annals of hepatology},
  volume={3 4},
Abstract Bile is primarily secreted in hepatocytes (i.e. the canalicular bile) and subsequently delivered to the intrahepatic bile ducts, where is modified by cholangiocytes (i.e. the ductal bile). Bile formation is the result of the coordinated interactions of membrane-transport systems that generate the vectorial movement of solutes and osmotically driven water molecules. Hepatocytes and cholangiocytes express aquaporins, specialized membrane channel proteins that facilitate the osmotic… CONTINUE READING


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