Liver and kidney disease in ciliopathies.

@article{GunayAygun2009LiverAK,
  title={Liver and kidney disease in ciliopathies.},
  author={Meral Gunay-Aygun},
  journal={American journal of medical genetics. Part C, Seminars in medical genetics},
  year={2009},
  volume={151C 4},
  pages={296-306}
}
Hepatorenal fibrocystic diseases (HRFCDs) are among the most common inherited human disorders. The discovery that proteins defective in the autosomal dominant and recessive polycystic kidney diseases (ADPKD and ARPKD) localize to the primary cilia and the recognition of the role these organelles play in the pathogenesis of HRFCDs led to the term "ciliopathies." While ADPKD and ARPKD are the most common ciliopathies associated with both liver and kidney disease, variable degrees of renal and/or… CONTINUE READING
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