Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.

@article{Schindhelm2005LiverAA,
  title={Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.},
  author={Roger Karlo Schindhelm and Michaela Diamant and Stephan J L Bakker and Robert A J M van Dijk and Peter G. Scheffer and Tom Teerlink and Piet J. Kostense and R. Heine},
  journal={European journal of clinical investigation},
  year={2005},
  volume={35 6},
  pages={369-74}
}
BACKGROUND Plasma levels of liver transaminases, including alanine aminotransferase (ALT), are elevated in most cases of nonalcoholic fatty liver disease (NAFLD). Elevated ALT levels are associated with insulin resistance, and subjects with NAFLD have features of the metabolic syndrome that confer high-risk cardiovascular disease. Alanine aminotransferase predicts the development of type 2 diabetes (DM2) in subjects with the metabolic syndrome. However, the role of elevated ALT levels in… CONTINUE READING
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